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SURVEILLANCES UMMARY
A total of 23196 cases of monkeypox have been identified through IHR mechanisms and official public sources up to 06 September 2022, 14:00, from 43 countries and areas throughout the European region. Case-based data were reported for 23003 cases from 36 countries and areas to the European Centre for Disease Prevention and Control (ECDC) and the World Health Organization (WHO) Regional Office for Europe through TheEuropeanSurveillance System(TESSy), up to06September2022,10:00. Of the 23003 cases reported in TESSy, 22851 were laboratory confirmed. Furthermore, where sequencing was available, 372 were confirmed to belong to Clade II, formerly known as the West African clade. The earliest known case has a specimen date of 07 March 2022 and was identified through retrospective testing of a residual sample. The earliest date of symptom onset was reported as 03 April 2022. The majority of cases were between 31 and 40 years-old (9113/22960- 40%) and male (22633/22947- 98.6%). Out of the 9682 male cases with known sexual orientation, 97% self-identified as men who have sex with men. Among cases with known HIV status,37%(3406/9274) were HIV-positive. The majority of cases presented with a rash (10889/14241- 76.5%) and systemic symptoms such as fever, fatigue, muscle pain, chills, or headache (9705/14241- 68%). 638 cases were hospitalised (6%), of which 212 cases required clinical care. Five cases were admitted to ICU, of which three were reported to have died of monkeypox. To date, WHO and ECDC have been informed of 87 cases of MPX infection among health workers, including three cases of occupational exposure. In all three cases of occupational exposure, health workers were wearing recommended personal protective equipment but were exposed to body fluid while collecting samples. The WHO interim guidance on clinical management and infection prevention and control of rmonkeypox remains valid and is available at https://www.who.int/publications/i/item/WHO-MPX-Surveillance-2022.3