Accelerating work to overcome the global impact of neglected tropical diseases. A roadmap for implementation: Executive summary

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The vision of controlling, eliminating and eradicating neglected tropical diseases has gathered significant momentum over recent years.

The World Health Organization (WHO) has produced overwhelming evidence to show that the burden caused by many of the 17 diseases1 that affect more than 1 billion people worldwide can be effectively controlled and, in many cases, eliminated or even eradicated.

In 2003, WHO began to focus control measures away from specific diseases to the health needs of poor communities.2 This led to the introduction of two major strategic interventions:

• preventive chemotherapy, an intervention that allows the regular and coordinated administration of quality-assured, safe, singledose medicines on a large scale for the following diseases: foodborne trematode infections, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiases and trachoma;

• intensified disease management, directed at neglected tropical diseases for which simple tools and treatments are not yet available, such as Buruli ulcer, endemic treponematoses (yaws), leprosy (Hansen disease), Chagas disease, human African trypanosomiasis (sleeping sickness), leishmaniasis, cysticercosis and echinococcosis.

Specific intervention approaches are required for dengue, dracunculiasis (guinea-worm disease) and human dogmediated rabies.