The International Federation’s Disaster Relief Emergency Fund (DREF) is a source of un-earmarked money created by the Federation in 1985 to ensure that immediate financial support is available for Red Cross and Red Crescent response to emergencies. The DREF is a vital part of the International Federation’s disaster response system and increases the ability of national societies to respond to disasters.<P>CHF 195,182 was allocated from the Federation’s Disaster Relief Emergency Fund (DREF) on 4 January 2011 to support the Uganda Red Cross Society (URCS) in delivering assistance to some 2,135,700 beneficiaries in 5 districts to protect them from contracting Yellow Fever.<P>Since confirming a Yellow Fever outbreak in 5 districts in Northern Uganda, URCS joined the national and district level task forces and supported a range of activities related to health promotion and education that increased community awareness about the disease’s modes of transmission, identification and preventive measures as well as facilitating the emergency vaccination activities that reached a coverage of 80.3%. Together, such activities effectively disrupted the spread of the disease in the 5 districts. By the time of reporting, the cumulative number of cases reached 246 with 56 deaths (CFR=22.8%) with no new cases reported since February 2011.<P>This operation was implemented within 2 months, and completed by 28 February 2011.<P>The URCS is grateful to the Belgian Red Cross and the European Commission Humanitarian Office (ECHO) for their support in replenishing this DREF.The major donors and partners of DREF include the Australian, American and Belgian governments, the Austrian Red Cross, the Canadian Red Cross and government, Danish Red Cross and government, the European Commission Humanitarian Aid and Civil Protection (ECHO), the Irish and the Italian governments, the Japanese Red Cross Society, the Luxembourg government, the Monaco Red Cross and government, the Netherlands Red Cross and government, the Norwegian Red Cross and government, the Spanish Government, the Swedish Red Cross and government, the United Kingdom Department for International Development (DFID), the Medtronic and Zurich Foundations, and other corporate and private donors. Thanks are extended to all for their generous contributions.