Every child deserves to reach her or his full potential wherever they live. Yet, achieving positive child well-being outcomes remains a challenge globally. COVID-19 has further exacerbated children’s existing vulnerabilities and amplified inequalities, especially in fragile contexts. As part of its mandate to help the most vulnerable children achieve their full potential, World Vision focuses on child well-being programmes that aim to improve key child well-being outcomes. Ten years of conflict in Syria have aggravated gender inequalities and the risks of violence for women and girls inside and outside the country. To increase the focus on gender-responsive programmes that respond to the strategic needs of women, World Vision (WV) Syria Response conducted a piece of research that aimed to better understand the connection between Syrian mothers’ and children’s well-being and identify impactful approaches that effectively address both. Specifically, the research explored women’s empowerment and children’s well-being factors in Syria and selected host countries. It looked at how women’s socio-demographic factors and empowerment components influence physical, emotional, mental, and psycho-social child well-being. A cross-sectional observation methodology was developed using convenience sampling in Northwest Syria (NWS) and Government of Syria (GoS) areas, Jordan, and Turkey. The research targeted World Vision’s beneficiary children living in structured families and their mothers. The survey results were complemented key informant interviews (KIIs) with mothers and their children.