- On 7 February 2025, a mpox outbreak was declared in South Sudan after identifying one patient in Juba. The case originates from Uganda where a mpox outbreak is ongoing. South Sudan became the 22nd country to be affected by mpox in Africa.
- The National Ministry of Health, together with the WHO, have started contact tracing and activated the Public Health Emergency Operations Center in order to coordinate surveillance, preparedness and response and to contain the outbreak.
- An increased border monitoring has been established at the five main entry points into South Sudan with three high-risk neighbouring countries (the Democratic Republic of the Congo, Uganda, and Kenya.) In addition, an increased surveillance for Ebola virus disease (EBV) is also established at the main border crossing with Uganda where an EBV outbreak is ongoing.
- South Sudan is also facing cholera outbreak since October 2024
South Sudan + 3 more