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Summary of the situation in the Americas Region
In the Americas Region, during 2025, and as of epidemiological week (EW) 53, 4,459,521 1 and 1,682,588 confirmed dengue cases were reported to the Pan American Health Organization (PAHO) Health Information Platform for the Americas (PLISA per its acronym in Spanish) (1). Of this total, 8,966 (0.2%) were characterized as severe dengue, and 2,207 deaths were recorded (case fatality rate of 0.05%) (1). The total number of cases reported through PLISA in 2025 shows a similar trend to that observed in non-epidemic years (Figure 1) (1), showing a 66% decrease compared to 2024, a year in which there was a historic increase in reported dengue cases in the Americas Region (n= 13,063,434 cases) (1, 2). During 2026, as of EW 4, 122,090 cases have been reported, including 22,409 laboratory-confirmed cases, 242 cases of severe dengue, and six deaths (1).
During 2025, circulation of all four dengue virus serotypes was identified in the Americas Region. Brazil, Colombia, Costa Rica, El Salvador, Mexico, Panama, and Puerto Rico reported simultaneous circulation of all four serotypes (DENV-1, DENV-2, DENV-3, and DENV-4). In addition, Argentina, Ecuador, Guatemala, Paraguay, and Peru reported simultaneous circulation of DENV-1, DENV-2, and DENV-3 (1).