Up to 6 May 2009, the total of confirmed cases of influenza A (H1N1) recorded is 2,214 including 44 deaths, in 7 countries of the Americas (Mexico, United States, Canada, Costa Rica, Colombia, El Salvador and Guatemala).

To date, the United States has confirmed a total of 896 human cases of influenza A (H1N1) including 2 deaths, in 41 States: 4 in Alabama, 48 in Arizona, 106 in California, 17 in Colorado, 4 in Connecticut, 38 in Delaware, 5 in Florida, 3 in Georgia, 3 in Hawaii, 1 in Idaho, 204 in Illinois, 15 in Indiana, 5 in Iowa, 7 in Kansas, 2 in Kentucky, 7 in Louisiana, 4 in Maine, 4 in Maryland, 71 in Massachusetts, 1 in Michigan, 1 in Minnesota, 4 in Missouri, 4 in Nebraska, 5 in Nevada, 2 in New Hampshire, 7 in New Jersey, 8 in New México, 98 in New York, 7 in North Carolina, 5 in Ohio, 1 in Oklahoma, 15 in Oregon, 2 in Pennsylvania, 2 in Rhode Island, 17 in South Carolina, 2 in Tennessee, 91 in Texas, 8 in Utah, 11 in Virginia, 23 in Washington and 26 in Wisconsin. Other suspected cases are being investigated.

From 1 March to 5 May, Mexico has reported 1,112 confirmed cases of influenza A (H1N1), including 42 deaths, in 28 of 32 States. The states with the highest number of confirmed cases are Distrito Federal, Estado de Mexico, San Luis Potosi and Hidalgo. The majority of these have occurred in previously healthy young adult people.

In Canada, to date 201 human cases of influenza A (H1N1) have been confirmed in 8 of 13 Provinces: (30 in Alberta, 54 in British Columbia, 2 in New Brunswick, 53 in Nova Scotia, 10 in Quebec, 1 in Manitoba, 49 in Ontario and 2 in Prince Edward Island), some of them with recent travel history to Mexico. All the cases developed a mild form of influenza-like illness. Some of the cases presented, in addition, gastrointestinal symptoms. Indigenous transmission is not discarded since not all the confirmed cases have trip history to Mexico

On 2 May, Costa Rica notified 1 confirmed case of influenza A (H1N1). On 3 May, Colombia reported 1 confirmed case of influenza A (H1N1), while El Salvador reported 2 confirmed cases of influenza A (H1N1). On 5 May, Guatemala notified 1 confirmed case of influenza A (H1N1) in a person that has travelled to Mexico.Various countries of the Region are reporting suspected and probable cases. This indicates that surveillance enhancement is producing results.